Certain applications such as processing nanoparticles, often require long processing times. Using a larger probe will speed up processing and larger probes will not erode as quickly as smaller ones.
For example, using an Integrated Type Homogenizer with a ½” diameter probe will process a 50ml sample much faster than same Integrated Type Homogenizer with a ¼” probe. In addition, smaller probes wear out faster and will need to be replaced more often. Over time using a larger system will end up costing less as you factor in the replacement cost of multiple probes.